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Archive for August, 2009

UNE chemists present work at AIMECS, the Asian International Medicinal Chemistry Symposium

Monday, August 31st, 2009

Rhiannon Schumacher, a postgraduate student in the Bio-organic chemistry group recently presented her work at the AIMECS meeting in Cairns. Seen here in discussions at her poster session, Rhiannon reported her latest findings on a poster entitled “Pushing the limits of Lipinski’s log P with polycyclic aromatics” . The paper, which also reported earlier work by Tony Banks (Ph.D.,2003) and Sam Clay (B.Sc. Hon., 2003) dealt with her latest mutagenicity studies of N-acyloxy-N-alkoxyamides, which show that DNA can be targeted by molecules bearing simple polycyclic aromatics like naphthalene and pyrene

Rhiannon Schumacher presenting at AIMECS

Prof Steve Glover also presented a paper on work carried out in collaboration with Prof Mike Novak and Yue-Ting Wang at Miami University and entitled “Phenyloxenium Ions from Hydrolysis of 4-Acetoxy-4-(benzothiazol-2-yl)-2,5-cyclohexadien-1-one, a Model Anti-Tumor Quinol Ester”. In this paper, theoretical evidence was presented which points to a role of reactive oxenium ions in the anticancer activity of these quinol esters.

International conference presentations in July

Monday, August 31st, 2009
ESOC venue in Prague

ESOC venue in Prague - the Municipal Concert Hall

Professor Glover recently attended two conferences in the Czech republic. From 5-10 July, he attended ISRIUM 2009, the International Symposium on Reactive Intermediates and Unusual Molecules held in Liblice near Prague. He presented a paper entitled

“Identification of an Aryloxenium Ion by Time Resolved Resonance Raman (TR3) Spectroscopy and Density Functional Theory: First Vibrational Spectrum of an Oxenium Ion” by Stephen Glover, Michael Novak and Yue-Ting Wang (Miami University), David Phillips and Jiadan Xue (Hong Kong)

He also presented UNE research at ESOC 2009, the 16th European Symposium on Organic Chemistry, which was held between 12-16 July in the beautiful capital Prague.

“Mutagenicity of N-Acyloxy-N-alkoxyamides —New Substituent Effects” by
Stephen Glover, Samuel Clay, Kate Cavanagh, and Rhiannon Schumacher

Recent publications from the Bio-organic group

Monday, August 31st, 2009

1. Feature article in the Journal of Organic Chemistry:

Hydrolysis and Photolysis of 4-Acetoxy-4-(benzothiazol-2-yl)-2,5-cyclohexadien-1-one, a Model Anti-Tumor Quinol Ester.
Y.-T. Wang, K. J. Jin, L. R. Myers, S. A. Glover and M. Novak, J. Org. Chem., 2009, 74, 4463-4471.

2. Invited paper in the Organic08, the Australian Journal of Chemistry’s Special Edition on the 23 rd conference of the Organic Division in Hobart, December 2008:

SN2 Substitution Reactions at the Amide Nitrogen in the Anomeric Mutagens, N-Acyloxy-N-alkoxyamides.
K. L. Cavanagh, S. A. Glover, H. L. Price and R. R. Schumacher, Aust. J. Chem., 2009, 62, 700-710.