Rhiannon Schumacher, a postgraduate student in the Bio-organic chemistry group recently presented her work at the AIMECS meeting in Cairns. Seen here in discussions at her poster session, Rhiannon reported her latest findings on a poster entitled “Pushing the limits of Lipinski’s log P with polycyclic aromatics” . The paper, which also reported earlier work by Tony Banks (Ph.D.,2003) and Sam Clay (B.Sc. Hon., 2003) dealt with her latest mutagenicity studies of N-acyloxy-N-alkoxyamides, which show that DNA can be targeted by molecules bearing simple polycyclic aromatics like naphthalene and pyrene
Prof Steve Glover also presented a paper on work carried out in collaboration with Prof Mike Novak and Yue-Ting Wang at Miami University and entitled “Phenyloxenium Ions from Hydrolysis of 4-Acetoxy-4-(benzothiazol-2-yl)-2,5-cyclohexadien-1-one, a Model Anti-Tumor Quinol Ester”. In this paper, theoretical evidence was presented which points to a role of reactive oxenium ions in the anticancer activity of these quinol esters.